Season five of Murdoch Mysteries opens in unfamiliar territory, as Detective William Murdoch (Yannick Bisson) leaves Toronto to try his luck while the Klondike Gold Rush in the Yukon winds down. Suspended for interfering in an investigation, on the run for surreptitiously freeing a murderer to make amends, and nursing a broken heart after Dr. Ogden's marriage to another man, he tries to escape his past, and his passion for detective work. Back in the city, newly promoted Chief Constable Giles (Nigel Bennett) makes it clear to Inspector Thomas Brackenreid (Thomas Craig), that he'll be keeping a very close eye on police matters. Meanwhile, Murdoch's beloved former associate, Dr. Julia Ogden (Hélène Joy), is now working alongside Acting Detective George Crabtree (Jonny Harris) and Dr. Emily Grace (Georgina Reilly), a feisty young protégé. In the remote north, Murdoch is pleased to discover that his fledgling prospecting career may garner great success, a small comfort after Julia's marriage to another man. But as he tries to rebuild his life, he finds himself drawn into the case of Mrs. Elizabeth Bryant (Jill Halfpenny), an innkeeper charged with murder. The plot thickens when writer Jack London (Aaron Ashmore) lends his insights, and Murdoch soon realizes that while he had hoped to leave his shattered heart and tattered career back in Toronto, his days as a detective are not behind him.

艾莉森·珍妮将出演J·J·艾布拉姆斯的坏机器人公司打造的惊悚片[卢](Lou，暂译)。该片由安娜·福斯特执导，玛吉·科恩重新撰写杰克·斯坦利的剧本，讲述了一个年轻女子和她房东卢(Lou)的故事。珍妮将会扮演这个强硬的打破常规的女房东，她有着惊人的跟踪能力和其他技能。本片预计2019年春开拍。

在一场意外中，芭芭拉（朱迪思·欧迪 Judith O'Dea 饰）和哥哥遭到了丧尸的袭击，这些活死人个性凶残样貌可怖，在它们的脑袋里，只装了一件事情，那就是“吃”。受伤的哥哥不幸感染了病毒成为了丧尸中的一员，悲痛和恐惧之中，芭芭拉逃进了一间民宅内，在那里，她遇见了同样在此躲避丧尸的本（杜安·琼斯 Duane Jones 饰）。　　藏在这间屋子里的并不止芭芭拉和本两人，汤姆（Keith Wayne 饰）、朱迪（Judith Ridley 饰）、哈里（Karl Hardman 饰）和海伦（Kyra Schon 饰）等人纷纷加入了避难的队伍，面对屋外越来越多的丧尸，众人知道，如果不能主动出击，那么只有死路一条。搜集仅有的武器，封锁门窗，在这一危急时刻，每一个人都在为了生存而战斗着。